本期文献交流内容：

时间：2016-10-27（星期四）13:30

地点：实验室一楼

文献一：

Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.

From：PNAS   IF：9.423  2013.7.13  Author：Natalia Sacilotto

报告人：李艳楠

摘要：动脉是通过什么机制来建立和保持的，这一问题一直未被解决。尽管很多信号通路和转录调节因子参与了动静脉分化，但是没有一种是在静脉形成中是必须的，而且广泛表达的因子是以什么方式来参与动脉特异性基因的调节的？这些都是未知的。通过小鼠和斑马鱼双重模型，作者研究出了动脉特化是由Notch信号通路和SOXF转录因子共同直接激活转录基因来调控的。通过识别和表征两个NOTCH配体DLL4的动脉内皮细胞特异性基因增强子，发现动脉DLL4的表达需要RBPJ/NOTCH细胞内区域和SOXF转录因子的直接结合。

文献二:

Transcriptome Analysis and UPR Pathway.

报告人：黄玉婷

For Transcriptome analysis and discovery of genes,global transcriptome analysis,methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human,functional genomics tool for the Pacific bluefin tuna: development of aoligonucleotide microarray from whole-genome sequencing data,comparative analysis of transcriptomes in aerial stems and roots of ephedra sinica based on high-throughout  mRNA sequencing and so on.

About the multiple theory of the UPR pathways: combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators; the PERK eIF2 ATF4 module of the UPR in hypoxia resistance and tumor growth， tumor necrosis Factor α ,induces the unfolded protein response in a reactive oxygen species dependent fashion and the UPR counteracts ROS accumulation by TNF, the mitochondrial UPR protecting organelle protein homeostasis and the ER stress response getting the UPR hand on misfolded protein etc.