报告题目：Melanization and coagulation; important defence mechanisms in invertebrates

报告人：Kenneth Söderhäll教授

报告时间：11月4日15 : 30

报告地点：图书馆报告厅

报告人简介：Kenneth Söderhäll，瑞典乌普萨拉大学教授，世界著名发育与比较免疫学家，SCI期刊Developmental and Comparative Immunology主编。主要从事于无脊椎动物发育与比较免疫学研究，在解析节肢动物造血机制、酚氧化酶原系统激活及信号传导途径等方面开展了大量研究，先后在Nature、PNAS、Immunological Reviews、Trends in Immunology等国际知名期刊发表论文近300篇，为国际免疫学发展作出了巨大贡献。

报告概述：Melanization is present in principally all eukaryotic organisms and the end result of this reaction is the formation of melanin, which is toxic to microorganisms and fungi. The melanization comprises several proteases, protease inhibitors and phenoloxidase, a redox enzyme which converts phenols to melanin. If microorganisms enter the body cavity, they will release pattern recognition molecules from their cell walls and these PRMs will bind to pattern recognition receptors and induce activation of this proteolytic cascade and finally prophenoloxidase is cleaved by a protease, ppA and as a result melanization occurs. This enzyme cascade has been deciphered in detail, which will be discussed in this talk. The clotting reaction is similar to the last step in mammals since it consists of a transglutaminase and a clotting protein. The latter has no sequence similarity with fibrinogen.

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